reduced basal autophagy and impaired mitochondrial dynamics due to loss of parkinsons disease-associated protein dj-1减少基底自噬和受损的线粒体动力学由于dj-1帕金森疾病有关的蛋白质的损失.pdfVIP

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson’s Disease-Associated Protein DJ-1 1 2 1,3 1 1 Guido Krebiehl , Sabine Ruckerbauer , Lena F. Burbulla , Nicole Kieper , Brigitte Maurer , Jens 1¤ 4 5 6 7 8 Waak , Hartwig Wolburg , Zemfira Gizatullina , Frank N. Gellerich , Dirk Woitalla , Olaf Riess , 1 2 ¨ 1 Philipp J. Kahle , Tassula Proikas-Cezanne *, Rejko Kruger * ¨ ¨ 1 Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany, 2 Autophagy Laboratory, Interfaculty Institute for Cell ¨ ¨ ¨ Biology, University of Tubingen, Tubingen, Germany, 3 Graduate School of Cellular and Molecular Neuroscience, University of Tuebingen, Tubingen, Germany, 4 Institute ¨ ¨ KeyNeurotek of Pathology, University of Tubingen, Tubingen, Germany, 5 Department of Neurology, Otto von Guericke University of Magdeburg, Magdeburg, Germany, 6 Pharmaceuticals AG, ZENIT, Magdeburg, Germany, 7 Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany, 8 Department of Medical ¨ ¨ Genetics, University of Tubingen, Tubingen, Germany