原创力文档reduced physiological complexity in robust elderly adults with the apoe ε4 allele减少生理的复杂性与apoeε4健壮的老年人等位基因.pdfVIP
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reduced physiological complexity in robust elderly adults with the apoe ε4 allele减少生理的复杂性与apoeε4健壮的老年人等位基因
Reduced Physiological Complexity in Robust Elderly
Adults with the APOE e4 Allele
Daniel Cheng1., Shih-Jen Tsai2,3., Chen-Jee Hong2,3,4, Albert C. Yang3,5,6*
1 Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America, 2 Department
of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, 3 Divisions of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 4 Institute of
Brain Science, National Yang-Ming University, Taipei, Taiwan, 5 Department of Psychiatry, Chu-Tung Veterans Hospital, Hsin-Chu County, Taiwan, 6 Institute of Clinical
Medicine, National Yang-Ming University, Taipei, Taiwan
Abstract
Background: It is unclear whether the loss of physiological complexity during the aging process is due to genetic variations.
The APOE gene has been studied extensively in regard to its relationship with aging-associated medical illness. We
hypothesize that diminished physiological complexity, as measured by heart rate variability, is influenced by polymorphisms
in the APOE allele among elderly individuals.
Methodology/Principal Findings: A total of 102 robust, non-demented, elderly subjects with normal functions of daily
activities participated in this study (97 males and 5 females, aged 79.2 64.4 years, range 72–92 years). Among these
individuals, the following two APOE genotypes were represented: e4 non-carriers (n = 87, 85.3%) and e4 carriers (n = 15,
14.7%). Multi-scale entropy (MSE), an analysis used in quantifying complexity for nonlinear time series, was employed to
analyze heart-rate dynamics. Reduced physiological complexity, as measured by MSE, was significantly associated with the
presence of the APOE e4 allele in healthy elderly subjects, as compared to APOE e
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