rapid progressing allele hla-b35 px restricted anti-hiv-1 cd8+ t cells recognize vestigial ctl epitopes快速进展等位基因hla-b35 px限制anti-hiv-1 cd8 + t细胞识别残留细胞毒性t淋巴细胞抗原表位.pdfVIP

Rapid Progressing Allele HLA-B35 Px Restricted Anti- HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes 1 1 2 1 3 Christian B. Willberg , Keith E. Garrison , R. Brad Jones , Duncan J. Meiklejohn , Gerald Spotts , Teri J. 3 2 4,5 3 1 Liegler , Mario A. Ostrowski , Annika C. Karlsson , Frederick M. Hecht , Douglas F. Nixon * 1 Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, 2 Department of Immunology, University of Toronto, Toronto, Ontario, Canada, 3 Division of HIV/AIDS, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, 4 Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Solna, Sweden, 5 Department of Virology, The Swedish Institute for Infectious Disease Control, Solna, Sweden Abstract Background: The HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele. Methodology/Principal Findings: Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ individuals. Subjects expressing HLA- B*35-Px alleles showed no difference in response to the consensus epitopes compared to individuals with HLA-B*35-Py alleles. Surprisingly, all the HLA-B*35-Px+ individuals responded to epitope-variants even in the absence of a consensus response. Sequencing of the vir