原创力文档reduced neonatal mortality in meishan piglets a role for hepatic fatty acids降低新生儿死亡率在梅山仔猪肝脂肪酸的作用.pdfVIP
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reduced neonatal mortality in meishan piglets a role for hepatic fatty acids降低新生儿死亡率在梅山仔猪肝脂肪酸的作用
Reduced Neonatal Mortality in Meishan Piglets: A Role
for Hepatic Fatty Acids?
1. 1. 2 3 1
Hernan P. Fainberg , Katherine Bodley , Jaume Bacardit , Dongfang Li , Frank Wessely ,
1 4 5 1
Nigel P. Mongan , Michael E. Symonds , Lynne Clarke , Alison Mostyn *
1 School of Veterinary Medicine and Science, University of Nottingham, Leicestershire, United Kingdom, 2 School of Computer Science, University of Nottingham,
Nottingham, United Kingdom, 3 School of Biosciences, University of Nottingham, Leicestershire, United Kingdom, 4 Early Life Nutrition Research Unit, University of
Nottingham, Nottingham, United Kingdom, 5 Department of Agricultural Sciences, Imperial College Wye, Wye, Kent, United Kingdom
Abstract
The Meishan pig breed exhibits increased prolificacy and reduced neonatal mortality compared to commercial breeds, such
as the Large White, prompting breeders to introduce the Meishan genotype into commercial herds. Commercial piglets are
highly susceptible to hypoglycemia, hypothermia, and death, potentially due to limited lipid stores and/or delayed hepatic
metabolic ability. We therefore hypothesized that variation in hepatic development and lipid metabolism could contribute
to the differences in neonatal mortality between breeds. Liver samples were obtained from piglets of each breed on days 0,
7, and 21 of postnatal age and subjected to molecular and biochemical analysis. At birth, both breeds exhibited similar
hepatic glycogen contents, despite Meishan piglets having significantly lower body weight. The livers from newborn
Meishan piglets exhibited increased C18:1n9C and
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