reducing the impact of the next influenza pandemic using household-based public health interventions减少下一次流感大流行的影响使用分户的公共卫生干预措施.pdfVIP

PLoS MEDICINE Reducing the Impact of the Next Influenza Pandemic Using Household-Based Public Health Interventions 1,2[ 1[* 3 1 Joseph T. Wu , Steven Riley , Christophe Fraser , Gabriel M. Leung 1 Department of Community Medicine and School of Public Health, Faculty of Medicine, University of Hong Kong, Hong Kong, Special Administrative Region, People’s Republic of China, 2 School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America, 3 Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom Funding: The authors thank the A B S T R A C T following for research funding: the Research Fund for the Control of Infectious Diseases of the Health, Background Welfare and Food Bureau of the Hong Kong SAR Government (JTW, SR, and GML); the Georgia Cancer The outbreak of highly pathogenic H5N1 influenza in domestic poultry and wild birds has Coalition (JTW); the University of caused global concern over the possible evolution of a novel human strain [1]. If such a strain Hong Kong SARS Research Fund (SR emerges, and is not controlled at source [2,3], a pandemic is likely to result. Health policy in and GML); and the Royal Society of London (CF). The funders had no most countries will then be focused on reducing morbidity and mortality. role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Methods and Findings Competing Interests: The authors We estimate the expected reduction in primary attack rates for different household-based have declared that n