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reduction of malaria transmission to anopheles mosquitoes with a six-dose regimen of co-artemether减少疟疾传播按蚊与co-artemether six-dose方案.pdf

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reduction of malaria transmission to anopheles mosquitoes with a six-dose regimen of co-artemether减少疟疾传播按蚊与co-artemether six-dose方案

Open access, freely available online PLoS MEDICINE Reduction of Malaria Transmission to Anopheles Mosquitoes with a Six-Dose Regimen of Co-Artemether * Colin J. Sutherland , Rosalynn Ord, Sam Dunyo, Musa Jawara, Christopher J. Drakeley, Neal Alexander, Rosalind Coleman, Margaret Pinder, Gijs Walraven, Geoffrey A. T. Targett Immunology Unit and Infectious Diseases Epidemiology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom Competing Interests: The authors have declared that no competing A B S T R A C T interests exist. Author Contributions: CJS, SD, Background CJD, NA, RC, MP, GW, and GATT designed the study. CJS, RO, SD, Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is and MJ performed the experiments. increasing in prevalence in Africa. Combination therapy can both improve treatment and CJS, MJ, CJD, NA, MP, and GATT analyzed the data. CJS, RO, MJ, RC, provide important public health benefits if it curbs the spread of parasites harbouring MP, and GW enrolled patients. CJS, resistance genes. Thus, drug combinations must be identified which minimise gametocyte CJD, NA, RC, MP, GW, and GATT emergence in treated cases, and so prevent selective transmission of parasites resistant to any contributed to writing the paper. of the partner drugs. Academic Editor: Paul Garner, Liverpool School of Tropical Medicine, United Kingdom Methods and Findings Citation: Sutherland CJ, Ord R, In a randomised controlled trial, 497 children with uncomplicated falciparum malaria were Dunyo S, Jawara M, Drakeley CJ, et treated with CQ and