rates of anti-tuberculosis drug resistance in kampala-uganda are low and not associated with hiv infection抗结核药物的耐药性在kampala-uganda低利率而不是与艾滋病毒感染有关.pdfVIP

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rates of anti-tuberculosis drug resistance in kampala-uganda are low and not associated with hiv infection抗结核药物的耐药性在kampala-uganda低利率而不是与艾滋病毒感染有关.pdf

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rates of anti-tuberculosis drug resistance in kampala-uganda are low and not associated with hiv infection抗结核药物的耐药性在kampala-uganda低利率而不是与艾滋病毒感染有关

Rates of Anti-Tuberculosis Drug Resistance in Kampala- Uganda Are Low and Not Associated with HIV Infection 1,3 2 3 4 3 Deus Lukoye , Frank G. J. Cobelens , Nicholas Ezati , Samuel Kirimunda , Francis E. Adatu , Joseph K. 5 5 3,4 Lule , Fred Nuwaha , Moses L. Joloba * 1 Public Health Department, Kampala City Council, Kampala, Uganda, 2 Center for Poverty-Related Communicable Diseases, Amsterdam Institute of Global Health and Development, Academic Medical Centre, Amsterdam, The Netherlands, 3 National Tuberculosis and Leprosy Programme, Kampala, Uganda, 4 Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda, 5 Makerere University School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda Abstract Background: Drug resistance among tuberculosis patients in sub-Saharan Africa is increasing, possibly due to association with HIV infection. We studied drug resistance and HIV infection in a representative sample of 533 smear-positive tuberculosis patients diagnosed in Kampala, Uganda. Methods/Principal Findings: Among 473 new patients, multidrug resistance was found in 5 (1.1%, 95% CI 0.3–2.5) and resistance to any drug in 57 (12.1%, 9.3–15.3). Among 60 previously treated patients this was 7 (11.7%, 4.8–22.6) and 17 (28.3%; 17.5–41.4), respectively. Of 517 patients with HIV results, 165 (31.9%, 27.9–36.1) tested positive. Neither multidrug (adjusted odds ratio (ORadj) 0.7; 95% CI 0.19–2.6) nor any resistance (ORadj 0.7; 0.43–1.3) was associated with HIV status. Primary resistance to any drug was