原创力文档reduction and return of infectious trachoma in severely affected communities in ethiopia减少和严重影响社区感染沙眼的回归在埃塞俄比亚.pdfVIP
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reduction and return of infectious trachoma in severely affected communities in ethiopia减少和严重影响社区感染沙眼的回归在埃塞俄比亚
Reduction and Return of Infectious Trachoma in Severely
Affected Communities in Ethiopia
1 2 2 2 1 1
Takele Lakew , Jenafir House , Kevin C. Hong , Elizabeth Yi , Wondu Alemayehu , Muluken Melese ,
2 2 2 2 2,3
Zhaoxia Zhou , Kathryn Ray , Stephanie Chin , Emmanuel Romero , Jeremy Keenan , John P.
Whitcher2,3,4,5, Bruce D. Gaynor2,3, Thomas M. Lietman2,3,4,5*
1 Orbis International, Addis Ababa, Ethiopia, 2 F.I. Proctor Foundation, University of California, San Francisco, United States of America, 3 Department of Ophthalmology,
University of California, San Francisco, United States of America, 4 Department of Epidemiology Biostatistics, University of California, San Francisco, United States of
America, 5 Institute for Global Health, University of California, San Francisco, United States of America
Abstract
Background: Antibiotics are a major tool in the WHO’s trachoma control program. Even a single mass distribution reduces
the prevalence of the ocular chlamydia that causes trachoma. Unfortunately, infection returns after a single treatment, at
least in severely affected areas. Here, we test whether additional scheduled treatments further reduce infection, and
whether infection returns after distributions are discontinued.
Methods: Sixteen communities in Ethiopia were randomly selected. Ocular chlamydial infection in 1- to 5-year-old children
was monitored over four biannual azithromycin distributions and for 24 months after the last treatment.
Findings: The average prevalence of infection in 1- to 5-year-old children was reduced from 63.5% pre-treatment to 11.
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