re-emergence of crimean-congo hemorrhagic fever virus in central africa克里米亚-刚果出血热病毒在非洲中部崛起.pdfVIP

Re-Emergence of Crimean-Congo Hemorrhagic Fever Virus in Central Africa 1 2 3 4 3,5 Gilda Grard *, Jan Felix Drexler , Joseph Fair , Jean-Jacques Muyembe , Nathan D. Wolfe , Christian Drosten2, Eric M. Leroy1,6 ´ 1 Centre International de Recherches Medicales de Franceville (CIRMF), Franceville, Gabon, 2 Institute of Virology, University of Bonn Medical Centre, Bonn, Germany, ´ 3 Global Viral Forecasting, San Francisco, California, United States of America, 4 Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo, 5 Department of Epidemiology, School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America, 6 Institut de Recherche ´ pour le Developpement (IRD), UMR 224 (MIVEGEC), IRD/CNRS/UM1, Montpellier, France Abstract Background: Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease well recognized through Europe and Asia where diagnostic tests and medical surveillance are available. However, it is largely neglected in Africa, especially in the tropical rainforest of Central Africa where only sporadic human cases have been reported and date back to more than 30 years. We describe here an isolated human case that occurred in the Democratic Republic of the Congo in 2008 and performed phylogenetic analysis to investigate whether it resulted from a regional re-emergence or from the introduction of a novel virus in the area. Methods and Findings: Near complete segment S and partia