repeated labilization-reconsolidation processes strengthen declarative memory in humans重复labilization-reconsolidation过程加强人类的陈述性记忆.pdfVIP

Repeated Labilization-Reconsolidation Processes Strengthen Declarative Memory in Humans ´ ´ ´ Cecilia Forcato, Marıa L. C. Rodrıguez, Marıa E. Pedreira* ´ ´ ´ Laboratorio de Neurobiologıa de la Memoria, Departamento de Fisiologıa, Biologıa Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE – CONICET, Buenos Aires, Argentina Abstract The idea that memories are immutable after consolidation has been challenged. Several reports have shown that after the presentation of a specific reminder, reactivated old memories become labile and again susceptible to amnesic agents. Such vulnerability diminishes with the progress of time and implies a re-stabilization phase, usually referred to as reconsolidation. To date, the main findings describe the mechanisms associated with the labilization-reconsolidation process, but little is known about its functionality from a biological standpoint. Indeed, two functions have been proposed. One suggests that destabilization of the original memory after the reminder allows the integration of new information into the background of the original memory (memory updating), and the other suggests that the labilization-reconsolidation process strengthens the original memory (memory strengthening). We have previously reported the reconsolidation of human declarative memories, demonstrating memory updating in the framework of reconsolidation. Here we deal with the strengthening function attributed to the reconsolidation process. We triggered labilization-reconsolidation processes successively by repeated presentations of the proper reminder. Participants learned an association between five cue-syllables and their respe