repeated ptz treatment at 25-day intervals leads to a highly efficient accumulation of doublecortin in the dorsal hippocampus of rats重复每隔25 ptz治疗会导致一种高效积累doublecortin背侧海马的老鼠.pdfVIP

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repeated ptz treatment at 25-day intervals leads to a highly efficient accumulation of doublecortin in the dorsal hippocampus of rats重复每隔25 ptz治疗会导致一种高效积累doublecortin背侧海马的老鼠.pdf

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repeated ptz treatment at 25-day intervals leads to a highly efficient accumulation of doublecortin in the dorsal hippocampus of rats重复每隔25 ptz治疗会导致一种高效积累doublecortin背侧海马的老鼠

Repeated PTZ Treatment at 25-Day Intervals Leads to a Highly Efficient Accumulation of Doublecortin in the Dorsal Hippocampus of Rats 1,2. 2. 1,2 2 2 Ana-Maria Buga , Raluca Vintilescu , Adrian Tudor Balseanu , Oltin Tiberiu Pop , Costin Streba , Emil Toescu3, Aurel Popa-Wagner1,2* 1 Department of Psychiatry, Molecular Psychiatry, Rostock University Medical School, Rostock, Germany, 2 Department of Functional Sciences, University of Medicine and Pharmacy, Craiova, Romania, 3 Department of Clinical and Experimental Medicine, College of Medical and Dental Sciences University of Birmingham Edgbaston, Birmingham, United Kingdom Abstract Background: Neurogenesis persists throughout life in the adult mammalian brain. Because neurogenesis can only be assessed in postmortem tissue, its functional significance remains undetermined, and identifying an in vivo correlate of neurogenesis has become an important goal. By studying pentylenetetrazole-induced brain stimulation in a rat model of kindling we accidentally discovered that 2561 days periodic stimulation of Sprague-Dawley rats led to a highly efficient increase in seizure susceptibility. Methodology/Principal Findings: By EEG, RT-PCR, western blotting and immunohistochemistry, we show that repeated convulsive seizures with a periodicity of 25 61 days led to an enrichment of newly generated neurons, that were BrdU- positive in the dentate gyrus at day 2561 post-seizure. At the same time, there was a massive increase in the number of neurons expressing the migratory marker, doublecortin, at the boundary between the granule cell layer and the polym