repetition enhancement for frequency-modulated but not unmodulated sounds a human meg study重复增强人类梅格调频但不是未调制的听起来研究.pdfVIP

Repetition Enhancement for Frequency-Modulated but Not Unmodulated Sounds: A Human MEG Study 1 1,2 1 3 1,4,5 Linda V. Heinemann *, Benjamin Rahm , Jochen Kaiser , Bernhard H. Gaese , Christian F. Altmann 1 Institute of Medical Psychology, Goethe University, Frankfurt am Main, Germany, 2 Medical Psychology and Sociology, University Medical Center of the Gutenberg University, Mainz, Germany, 3 Institute of Cell Biology and Neuroscience, Goethe University, Frankfurt am Main, Germany, 4 International Young Scientists Career Development Organization, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5 Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan Abstract Background: Decoding of frequency-modulated (FM) sounds is essential for phoneme identification. This study investigates selectivity to FM direction in the human auditory system. Methodology/Principal Findings: Magnetoencephalography was recorded in 10 adults during a two-tone adaptation paradigm with a 200-ms interstimulus-interval. Stimuli were pairs of either same or different frequency modulation direction. To control that FM repetition effects cannot be accounted for by their on- and offset properties, we additionally assessed responses to pairs of unmodulated tones with either same or different frequency composition. For the FM sweeps, N1m event-related magnetic field components were found at 103 and 130 ms after onset of the first (S1) and second stimulus (S2), respectively. This was followed by a sustained component starting at about 200 ms after S2. The sustained response was significantly stronger for stimulat