repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer曲目增强与女性淋巴细胞过继转移控制pre-implanted小鼠前列腺癌的生长.pdfVIP

Repertoire Enhancement with Adoptively Transferred Female Lymphocytes Controls the Growth of Pre- Implanted Murine Prostate Cancer 1,2. 3. 1 4 3 Robert R. Jenq , Michael A. Curran , Gabrielle L. Goldberg , Chen Liu , James P. Allison , Marcel R. M. van den Brink1* 1 Department of Immunology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, 2 Weill Cornell Medical College, New York, New York, United States of America, 3 Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, 4 Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, Florida, United States of America Abstract Background: In prostate cancer, genes encoding androgen-regulated, Y-chromosome-encoded, and tissue-specific antigens may all be overexpressed. In the adult male host, however, most high affinity T cells targeting these potential tumor rejection antigens will be removed during negative selection. In contrast, the female mature T-cell repertoire should contain abundant precursors capable of recognizing these classes of prostate cancer antigens and mediating effective anti-tumor immune responses. Methodology/Principal Findings: We find that syngeneic TRAMP-C2 prostatic adenocarcinoma cells are spontaneously ¨ rejected in female hosts. Adoptive transfer of naıve female lymphocytes to irradiated male hosts bearing pre-implanted TRAMP-C2 tumor cells slows tumor growth and mediates tumor rejection in some animals. The success of this adoptive