原创力文档reproductive factors and non-hodgkin lymphoma risk in the california teachers study生殖因素和非霍奇金淋巴瘤的风险在加州教师学习.pdfVIP
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reproductive factors and non-hodgkin lymphoma risk in the california teachers study生殖因素和非霍奇金淋巴瘤的风险在加州教师学习
Reproductive Factors and Non-Hodgkin Lymphoma Risk
in the California Teachers Study
1,2 3 4,5 3 3
Jennifer Prescott , Yani Lu , Ellen T. Chang , Jane Sullivan-Halley , Katherine D. Henderson ,
4,5 3 6 6 3
Christina A. Clarke , Huiyan Ma , Claire Templeman , Dennis Deapen , Leslie Bernstein *
1 Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, 2 Channing Laboratory, Department
of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 3 City of Hope National Medical Center,
Duarte, California, United States of America, 4 Northern California Cancer Center, Fremont, California, United States of America, 5 Division of Epidemiology, Department of
Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America, 6 Department of Preventive Medicine, Norris
Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
Abstract
Background: Non-Hodgkin lymphoma (NHL) is a malignancy etiologically linked to immunomodulatory exposures and
disorders. Endogenous female sex hormones may modify immune function and influence NHL risk. Few studies have
examined associations between reproductive factors, which can serve as surrogates for such hormonal exposures, and NHL
risk by subtype.
Methodology/Principal Findings: Women in the California Teachers Study cohort provided detailed data in 1995–1996 on
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