原创力文档regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model调节视网膜局部antiglaucomatous眼药水蛋白质组的一种遗传青光眼鼠模型.pdfVIP
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regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model调节视网膜局部antiglaucomatous眼药水蛋白质组的一种遗传青光眼鼠模型
Regulation of Retinal Proteome by Topical
Antiglaucomatous Eye Drops in an Inherited Glaucoma
Rat Model
1,2 1 1
Maurice Schallenberg , Verena Prokosch , Solon Thanos *
¨ ¨
1 Institute of Experimental Ophthalmology, School of Medicine, University Clinics Munster and Interdisciplinary Centre for Clinical Research (IZKF), Munster, Germany,
2 Department of Ophthalmology, University of Duisburg-Essen, University Hospital Essen, Essen, Germany
Abstract
Examination of the response of the retinal proteome to elevated intraocular pressure (IOP) and to the pharmacological
normalization of IOP is crucial, in order to develop drugs with neuroptorective potential. We used a hereditary rat model of
ocular hypertension to lower IOP with travaprost and dorzolamide applied topically on the eye surface, and examine
changes of the retinal proteome. Our data demonstrate that elevated IOP causes alterations in the retinal protein profile, in
particular in high-mobility-group-protein B1 (HMGB1), calmodulin, heat-shock-protein (HSP) 70 and carbonic anhydrase II
expression. The changes of the retinal proteome by dorzolamide or travoprost are different and independent of the IOP
lowering effect. This fact suggests that the eye drops exert a direct IOP-independent effect on retinal metabolism. Further
investigations are required to elucidate the potential neuroprotective mechanisms signaled through changes of HMGB1,
calmodulin, HSP70 and carbonic anhydrase II expression in glaucoma. The data may facilitate development of eye drops
that exert neuroprotection through direct pharmacological effect.
Citation: Schallenberg M, Prokosch V, Thano
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