原创力文档ribonuclease activity of dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function核糖核酸酶dis3的活动需要有丝分裂进程,提供了一个可能的异染色质与着丝粒函数之间的联系.pdfVIP
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ribonuclease activity of dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function核糖核酸酶dis3的活动需要有丝分裂进程,提供了一个可能的异染色质与着丝粒函数之间的联系
Ribonuclease Activity of Dis3 Is Required for Mitotic
Progression and Provides a Possible Link between
Heterochromatin and Kinetochore Function
1 2¤ 3 4 4 2 1
Hiroaki Murakami , Derek B. Goto , Takashi Toda , Ee Sin Chen , Shiv I. Grewal , Robert A. Martienssen , Mitsuhiro Yanagida *
1 CREST Research Program, Japan Science and Technology Corporation, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto
University, Yoshida-Honmachi, Sakyo-ku, Kyoto, Japan, 2 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America,
3 Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom,
4 Laboratory of Molecular Cell Biology, National Institutes of Health, Bethesda, Maryland, United States of America
Background. Cellular RNA metabolism has a broad range of functional aspects in cell growth and division, but its role in
chromosome segregation during mitosis is only poorly understood. The Dis3 ribonuclease is a key component of the RNA-
processing exosome complex. Previous isolation of the dis3-54 cold-sensitive mutant of fission yeast Schizosaccharomyces
pombe suggested that Dis3 is also required for correct chromosome segregation. Methodology/Principal Findings. We show
here that the progression of mitosis is arrested in dis3-54, and that segregation of the chromosomes is blocked by activation of
the mitotic checkpoint control. This block is dependent on the Mad2 checkpoint protein. Double mutant and inhibitor analyses
revealed that Dis3 is required for correct kinetochore formation and function, and that this activity is monitored by the Mad2
checkpoint. Dis3 is a member of the highly conserved RNase II family and is known to be
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