rescue of a h3n2 influenza virus containing a deficient neuraminidase protein by a hemagglutinin with a low receptor-binding affinity拯救包含缺陷的h3n2流感病毒神经氨酸酶蛋白血凝素与受体结合的亲和力较低.pdfVIP

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rescue of a h3n2 influenza virus containing a deficient neuraminidase protein by a hemagglutinin with a low receptor-binding affinity拯救包含缺陷的h3n2流感病毒神经氨酸酶蛋白血凝素与受体结合的亲和力较低.pdf

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rescue of a h3n2 influenza virus containing a deficient neuraminidase protein by a hemagglutinin with a low receptor-binding affinity拯救包含缺陷的h3n2流感病毒神经氨酸酶蛋白血凝素与受体结合的亲和力较低

Rescue of a H3N2 Influenza Virus Containing a Deficient Neuraminidase Protein by a Hemagglutinin with a Low Receptor-Binding Affinity 1 1 ´ 2 ´ 1 ´ ´ 1 Mathilde Richard *, Alexandra Erny , Bertrand Care , Aurelien Traversier , Mendy Barthelemy , 2 2 1 1 Alan Hay , Yi Pu Lin , Olivier Ferraris , Bruno Lina ´ ´ ´ ´ 1 Laboratoire Virologie et Pathologie Humaine (VirPath), EMR 4610 – UCBL, Faculte de Medecine RTH Laennec, Universite de Lyon, Lyon cedex, France, 2 Universite de Lyon, CNRS, INRIA, INSA-Lyon, LIRIS, UMR5205, F-69621, Lyon, France, 3 The National Institute for Medical Research, Mill Hill, London, United Kingdom Abstract Influenza viruses possess at their surface two glycoproteins, the hemagglutinin and the neuraminidase, of which the antagonistic functions have to be well balanced for the virus to grow efficiently. Ferraris et al. isolated in 2003–2004 viruses lacking both a NA gene and protein (H3NA- viruses) (Ferraris O., 2006, Vaccine, 24(44–46):6656-9). In this study we showed that the hemagglutinins of two of the H3NA- viruses have reduced affinity for SAa2.6Gal receptors, between 49 and 128 times lower than that of the A/Moscow/10/99 (H3N2) virus and no detectable affinity for SAa2.3Gal receptors. We also showed that the low hemagglutinin affinity of the H3NA- viruses compensates for the lack of NA activity and allows the restoration of the growth of an A/Moscow/10/99 virus deficient in neuraminidase. These observations increase our u