原创力文档regulatory adaptation of staphylococcus aureus during nasal colonization of humans监管改编的金黄色葡萄球菌在鼻殖民统治人类.pdfVIP
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regulatory adaptation of staphylococcus aureus during nasal colonization of humans监管改编的金黄色葡萄球菌在鼻殖民统治人类
Regulatory Adaptation of Staphylococcus aureus during
Nasal Colonization of Humans
¤
Marc Burian , Christiane Wolz, Christiane Goerke*
¨ ¨ ¨ ¨ ¨
Interfakultares Institut fur Mikrobiologie und Infektionsmedizin, Universitat Tubingen, Tubingen, Germany
Abstract
The nasopharynx is the main ecological niche of the human pathogen Staphylococcus aureus. Although colonization of the
nares is asymptomatic, nasal carriage is a known risk factor for endogenous staphylococcal infection. We quantified S.
aureus mRNA levels in nose swabs of persistent carriers to gain insight into the regulatory adaptation of the bacterium to
the nasal environment. We could elucidate a general response of the pathogen to the surrounding milieu independent of
the strain background or the human host. Colonizing bacteria preferentially express molecules necessary for tissue
adherence or immune-evasion whereas toxins are down regulated. From the analysis of regulatory loci we found evidence
for a predominate role of the essential two-component system WalKR of S. aureus. The results suggest that during persistent
colonization the bacteria are metabolically active with a high cell surface turnover. The increased understanding of bacterial
factors that maintain the colonization state can open new therapeutic options to control nasal carriage and subsequent
infections.
Citation: Burian M, Wolz C, Goerke C (2010) Regulatory Adaptation of Staphylococcus aureus during Nasal Colonization of Humans. PLoS ONE 5(4): e10040.
doi:10.1371/journal.pone.0010040
Editor: Adam J. Ratner, Columbia University, United States of America
Received January 25, 2010; Accepted March 12, 2010; Published April 6, 2010
Copyright: 2010 Burian et al. This
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