原创力文档regulator of g-protein signaling 14 (rgs14) is a selective h-ras effector监管机构的蛋白信号14(rgs14)是一种选择性的h -效应.pdfVIP
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regulator of g-protein signaling 14 (rgs14) is a selective h-ras effector监管机构的蛋白信号14(rgs14)是一种选择性的h -效应
Regulator of G-Protein Signaling 14 (RGS14) Is a
Selective H-Ras Effector
1. 1. 1 4 1
Francis S. Willard *, Melinda D. Willard , Adam J. Kimple , Meera Soundararajan , Emily A. Oestreich ,
2 2 1,3 4 1,3
Xiaoyan Li , Nathaniel A. Sowa , Randall J. Kimple , Declan A. Doyle , Channing J. Der , Mark J.
2 2 1,2,3
Zylka , William D. Snider , David P. Siderovski *
1 Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America, 2 UNC Neuroscience Center, University of North
Carolina, Chapel Hill, North Carolina, United States of America, 3 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United
States of America, 4 Structural Genomics Consortium, Oxford University, Oxford, United Kingdom
Abstract
Background: Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Ga-mediated GTP
hydrolysis (‘‘GTPase-accelerating proteins’’ or GAPs). However, RGS proteins with complex domain architectures are now
known to regulate much more than Ga GTPase activity. RGS14 contains tandem Ras-binding domains that have been
reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion that RGS14 is a Rap-specific effector.
However, more recent data from mammals and Drosophila imply that
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