原创力文档regulatory cross-talk links vibrio cholerae chromosome ii replication and segregation监管相声链接霍乱弧菌ii号染色体复制和隔离.pdfVIP
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regulatory cross-talk links vibrio cholerae chromosome ii replication and segregation监管相声链接霍乱弧菌ii号染色体复制和隔离
Regulatory Cross-Talk Links Vibrio cholerae Chromosome
II Replication and Segregation
1 1,2 1 1,3
Yoshiharu Yamaichi , Matthew A. Gerding , Brigid M. Davis , Matthew K. Waldor *
1 Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Program in Biological and Biomedical
Sciences, Graduate School of Arts and Sciences, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Howard Hughes Medical Institute, Boston,
Massachusetts, United States of America
Abstract
There is little knowledge of factors and mechanisms for coordinating bacterial chromosome replication and segregation.
Previous studies have revealed that genes (and their products) that surround the origin of replication (oriCII) of Vibrio
cholerae chromosome II (chrII) are critical for controlling the replication and segregation of this chromosome. rctB, which
flanks one side of oriCII, encodes a protein that initiates chrII replication; rctA, which flanks the other side of oriCII, inhibits
rctB activity. The chrII parAB2 operon, which is essential for chrII partitioning, is located immediately downstream of rctA.
Here, we explored how rctA exerts negative control over chrII replication. Our observations suggest that RctB has at least
two DNA binding domains—one for binding to oriCII and initiating replication and the other for binding to rctA and thereby
inhibiting RctB’s ability to initiate replication. Notably, the inhibitory effect of rctA could be alleviated by binding of ParB2 to
a centromere-like parS site within rctA. Furthermore, by binding to rctA, ParB2 and RctB inversely regulate expression of the
parAB2 genes. Together, our findings su
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