原创力文档regulatory t cells in human lymphatic filariasis stronger functional activity in microfilaremics调节性t细胞在人类淋巴丝虫病microfilaremics强大的功能活动.pdfVIP
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regulatory t cells in human lymphatic filariasis stronger functional activity in microfilaremics调节性t细胞在人类淋巴丝虫病microfilaremics强大的功能活动
Regulatory T Cells in Human Lymphatic Filariasis:
Stronger Functional Activity in Microfilaremics
1,2 1,3 1,2 2 1
Linda J. Wammes *, Firdaus Hamid , Aprilianto E. Wiria , Heri Wibowo , Erliyani Sartono ,
4 1 2 1
Rick M. Maizels , Hermelijn H. Smits , Taniawati Supali , Maria Yazdanbakhsh *
1 Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands, 2 Department of Parasitology, University of Indonesia, Jakarta, Indonesia,
3 Department of Microbiology, Hasanuddin University, Makassar, Indonesia, 4 Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United
Kingdom
Abstract
Infection with filarial parasites is associated with T cell hyporesponsiveness, which is thought to be partly mediated by their
ability to induce regulatory T cells (Tregs) during human infections. This study investigates the functional capacity of Tregs
from different groups of filarial patients to suppress filaria-specific immune responses during human filariasis. Microfilaremic
(MF), chronic pathology (CP) and uninfected endemic normal (EN) individuals were selected in an area endemic for Brugia
timori in Flores island, Indonesia. PBMC were isolated, CD4CD25hi cells were magnetically depleted and in vitro cytokine
production and proliferation in response to B. malayi adult worm antigen (BmA) were determined in total and Treg-
depleted PBMC. In MF subjects BmA-specific T and B lymphocyte proliferation as well as IFN-gamma, IL-13 and IL-17
responses were lower compared to EN and CP groups. Depletion of Tregs restored T cell as well
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