reduction of n-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions减少n-glycolylneuraminic酸在人类诱导多能干细胞生成或无血清培养系统馈线和下定义的条件.pdfVIP

Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder- and Serum-Free Defined Conditions 1. 1. 2 3 1 Yohei Hayashi , Techuan Chan , Masaki Warashina , Masakazu Fukuda , Takashi Ariizumi , Koji 1 4 4 4 5 1 Okabayashi , Naoya Takayama , Makoto Otsu , Koji Eto , Miho Kusuda Furue , Tatsuo Michiue , Kiyoshi 1,6 4 1,7 Ohnuma *, Hiromitsu Nakauchi , Makoto Asashima * 1 Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan, 2 Genome Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan, 3 Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan, 4 Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 5 Laboratory of Cell Cultures, Department of Disease Bioresources, National Institute of Biomedical Innovation, Osaka, Japan, 6 Top Runner Incubation Center for Academia-Industry Fusion, Nagaoka University of Technology, Nagaoka, Japan, 7 Organ Development Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan Abstract Background: The successful establishment of human induced pluripotent stem cells (hiPSCs) has increased the possible applications of stem cell research in biology and medicine. In particular, hiPSCs are a promising source