原创力文档rationale and design of the leipzig (life) heart study phenotyping and cardiovascular characteristics of patients with coronary artery disease莱比锡的基本原理和设计(生活)心脏研究表现型和心血管患者冠状动脉疾病的特征.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
rationale and design of the leipzig (life) heart study phenotyping and cardiovascular characteristics of patients with coronary artery disease莱比锡的基本原理和设计(生活)心脏研究表现型和心血管患者冠状动脉疾病的特征
Rationale and Design of the Leipzig (LIFE) Heart Study:
Phenotyping and Cardiovascular Characteristics of
Patients with Coronary Artery Disease
Frank Beutner1,2,4, Daniel Teupser1,4*, Stephan Gielen2,4, Lesca Miriam Holdt1,4, Markus Scholz3,4, Enno
Boudriot2, Gerhard Schuler2,4, Joachim Thiery1,4
1 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany, 2 Department of Cardiology, Heart Center,
University Leipzig, Leipzig, Germany, 3 Institute of Medical Informatics, Statistic and Epidemiology, University Leipzig, Leipzig, Germany, 4 Leipzig Research Center for
Civilization Diseases (LIFE), University Leipzig, Leipzig, Germany
Abstract
Objective: We established the Leipzig (LIFE) Heart Study, a biobank and database of patients with different stages of
coronary artery disease (CAD) for studies of clinical, metabolic, cellular and genetic factors of cardiovascular diseases.
Design: The Leipzig (LIFE) Heart Study (NC is an ongoing observational angiographic study including subjects
with different entities of CAD. Cohort 1, patients undergoing first-time diagnostic coronary angiography due to suspected
stable CAD with previously untreated coronary arteries. Cohort 2, patients with acute myocardial infarction (MI) requiring
percutaneous revascularization. Cohort 3, patients with known left main coronary artery disease (LMCAD).
Results: We present preliminary results of demographics and phenotyping based on a 4-years analysis of a total of 3,165
subjects. Cohort 1 (n = 2,274) shows the typical distribution of elective coronary angiography cohorts with 43% cases with
obstructive CAD and 37% normal angiograms. Cohorts 2 and 3 consist of 590 and 301 subjects, respectively, adding patients
with severe forms of CAD. The suitability of the database and biobank to perform association studies was confirmed by
您可能关注的文档
- quantitative analysis of serum procollagen type i c-terminal propeptide by immunoassay on microchip定量分析血清胶原i型c端前肽的免疫测定微芯片.pdf
- quantitative analysis of cell nucleus organisation定量分析的细胞核组织.pdf
- quantitative analysis of peripheral tissue perfusion using spatiotemporal molecular dynamics定量分析的外围组织灌注使用时空分子动力学.pdf
- quantitative analysis of protein phosphorylations and interactions by multi-colour ip-fcm as an input for kinetic modelling of signalling networks定量分析蛋白质的磷酸化和交互的彩色ip-fcm作为输入信号网络的动力学模型.pdf
- quantitative analysis of focused a-to-i rna editing sites by ultra-high-throughput sequencing in psychiatric disorders定量分析集中a-to-i rna编辑网站的超高度大规模测序的精神疾病.pdf
- quantitative analysis of phase wave of gene expression in the mammalian central circadian clock network定量分析阶段波哺乳动物的中枢生物钟的基因表达网络.pdf
- quantitative analysis of single nucleotide polymorphisms within copy number variation定量分析的单核苷酸多态性在拷贝数变异.pdf
- quantitative 3.0t mr spectroscopy reveals decreased creatine concentration in the dorsolateral prefrontal cortex of patients with social anxiety disorder定量3.0 t磁共振光谱揭示了肌酸浓度降低社交焦虑障碍患者的背外侧前额叶皮层.pdf
- quantitative assessment of stereotyped and challenged locomotion after lesion of the striatum a 3d kinematic study in rats定量评估刻板和挑战运动损伤后大鼠的纹状体三维运动学的研究.pdf
- quantitative analysis of the effect of cancer invasiveness and collagen concentration on 3d matrix remodeling定量分析的影响癌症侵袭性和胶原蛋白浓度在3 d矩阵重构.pdf
- rational prescribing in primary care (rapp) a cluster randomized trial of a tailored interventionrational处方在初级保健(rapp)的集群随机试验的干预.pdf
- rasd1 modulates the coactivator function of nono in the cyclic amp pathwayrasd1调节环腺苷酸通路中的禁忌的共激活剂功能.pdf
- rationing antiretroviral therapy for hivaids in africa choices and consequences配给抗逆转录病毒疗法在非洲的条件选择和后果.pdf
- rational design of temperature-sensitive alleles using computational structure prediction设计合理的使用计算结构预测热敏等位基因.pdf
- raw and processed fruit and vegetable consumption and 10-year coronary heart disease incidence in a population-based cohort study in the netherlands原材料和加工过的水果和蔬菜消费和10年期冠心病发病率在荷兰以人群为基础的队列研究.pdf
- rats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractions老鼠低有氧能力迅速成为疲劳和代谢缓慢复苏刺激后,最大肌肉收缩.pdf
- rational mutational analysis of a multidrug mfs transporter camdr1p of candida albicans by employing a membrane environment based computational approach理性突变分析多种mfs运输车camdr1p白色念珠菌采用膜环境为基础的计算方法.pdf
- rates of mutation and host transmission for an escherichia coli clone over 3 years率的突变和主机传输大肠杆菌克隆3年以上.pdf
- rationality, irrationality and escalating behavior in lowest unique bid auctions理性、非理性和独特的最低投标拍卖行为升级.pdf
- rationale-based engineering of a potent long-acting fgf21 analog for the treatment of type 2 diabetesrationale-based工程的长效fgf21模拟治疗2型糖尿病.pdf
文档评论（0）