quantitative analysis of focused a-to-i rna editing sites by ultra-high-throughput sequencing in psychiatric disorders定量分析集中a-to-i rna编辑网站的超高度大规模测序的精神疾病.pdfVIP

Quantitative Analysis of Focused A-To-I RNA Editing Sites by Ultra-High-Throughput Sequencing in Psychiatric Disorders 1 1 1 1 1 Hu Zhu , Daniel J. Urban , Jared Blashka , Matthew T. McPheeters , Wesley K. Kroeze , 2 3 4,5 3 6 Piotr Mieczkowski , James C. Overholser , George J. Jurjus , Lesa Dieter , Gouri J. Mahajan , 6 1 2 4,6 1 Grazyna Rajkowska , Zefeng Wang , Patrick F. Sullivan , Craig A. Stockmeier , Bryan L. Roth * 1 Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, North Carolina, United States of America, 2 Department of Genetics, School of Medicine, Chapel Hill, North Carolina, United States of America, 3 Department of Psychology, Case Western Reserve University, Cleveland, Ohio, United States of America, 4 Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, United States of America, 5 Department of Psychiatry, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, United States of America, 6 Center for Psychiatric Neuroscience, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, United States of America Abstract A-to-I RNA editing is a post-transcriptional modification of single nucleotides in RNA by adenosine deamination, which thereby diversifies the gene products encoded in the genome. Thousands of potential RNA editing sites have been identified by recent studies