regulatory t cells in the pathogenesis and healing of chronic human dermal leishmaniasis caused by leishmania (viannia) species调节性t细胞在人类皮肤利什曼病的发病机理和治疗慢性由利什曼虫(viannia)物种.pdfVIP

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2017-09-09 发布于上海
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regulatory t cells in the pathogenesis and healing of chronic human dermal leishmaniasis caused by leishmania (viannia) species调节性t细胞在人类皮肤利什曼病的发病机理和治疗慢性由利什曼虫(viannia)物种.pdf

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regulatory t cells in the pathogenesis and healing of chronic human dermal leishmaniasis caused by leishmania (viannia) species调节性t细胞在人类皮肤利什曼病的发病机理和治疗慢性由利什曼虫(viannia)物种

Regulatory T Cells in the Pathogenesis and Healing of Chronic Human Dermal Leishmaniasis Caused by Leishmania (Viannia) Species 1 1 ´ 1 ´ 1 1 Daniel Rodriguez-Pinto *, Adriana Navas , Vıctor Manuel Blanco , Lady Ramırez , Daniel Garcerant , 1 2 1 Adriana Cruz , Noah Craft , Nancy Gore Saravia ´ 1 Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM), Cali, Colombia, 2 Division of Molecular Medicine, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America Abstract Background: The inflammatory response is prominent in the pathogenesis of dermal leishmaniasis. We hypothesized that regulatory T cells (Tregs) may be diminished in chronic dermal leishmaniasis (CDL) and contribute to healing during treatment. Methodology/Principal Findings: The frequency and functional capacity of Tregs were evaluated at diagnosis and following treatment of CDL patients having lesions of $6 months duration and asymptomatically infected residents of endemic foci. The frequency of CD4+CD25hi cells expressing Foxp3 or GITR or lacking expression of CD127 in peri- pheral blood was determined by flow cytometry. The capacity of CD4+CD25+ cells to inhibit Leishmania-specific responses was determined by co-culture with effector CD4+CD252 cells. The expression of FOXP3, IFNG, IL10 and IDO was determined in lesion and leishmanin skin