reduction in inflammatory gene expression in skeletal muscle from roux-en-y gastric bypass patients randomized to omentectomy减少炎症基因表达的骨骼肌roux - en - y胃旁路手术病人随机网膜切除术.pdfVIP

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reduction in inflammatory gene expression in skeletal muscle from roux-en-y gastric bypass patients randomized to omentectomy减少炎症基因表达的骨骼肌roux - en - y胃旁路手术病人随机网膜切除术.pdf

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reduction in inflammatory gene expression in skeletal muscle from roux-en-y gastric bypass patients randomized to omentectomy减少炎症基因表达的骨骼肌roux - en - y胃旁路手术病人随机网膜切除术

Reduction in Inflammatory Gene Expression in Skeletal Muscle from Roux-en-Y Gastric Bypass Patients Randomized to Omentectomy 1 1 2 1 1 Robyn A. Tamboli , Tahar Hajri , Aixiang Jiang , Pamela A. Marks-Shulman , D. Brandon Williams , 1 1 3 2 1 Ronald H. Clements , Willie Melvin , Benjamin P. Bowen , Yu Shyr , Naji N. Abumrad , Charles Robb Flynn1* 1 Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 2 Department of Cancer Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 3 Department of GTL Bioenergy and Structural Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America Abstract Objectives: To examine the effects of Roux-en-Y gastric bypass (RYGB) surgery with and without laparoscopic removal of omental fat (omentectomy) on the temporal gene expression profiles of skeletal muscle. Design: Previously reported were the whole-body metabolic effects of a randomized, single-blinded study in patients receiving RYGB surgery stratified to receive or not receive omentectomy. In this follow up study we report on changes in skeletal muscle gene expression in a subset of 21 patients, for whom biopsies were collected preoperatively and at either 6 months or 12 months postoperatively. Methodology/Principal Findings: RNA isolated from skeletal muscle biopsies of 21 subjects (8 without omentectomy and 13 with omentectomy) taken before RYGB or at 6 and 12 months postoperatively were subjected to gene expression