原创力文档regulatory t cell expansion in htlv-1 and strongyloidiasis co-infection is associated with reduced il-5 responses to strongyloides stercoralis antigen调节性t细胞扩张htlv 1和类圆线虫病合并感染与降低il-5反应类圆线虫属stercoralis抗原.pdfVIP
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regulatory t cell expansion in htlv-1 and strongyloidiasis co-infection is associated with reduced il-5 responses to strongyloides stercoralis antigen调节性t细胞扩张htlv 1和类圆线虫病合并感染与降低il-5反应类圆线虫属stercoralis抗原
Regulatory T Cell Expansion in HTLV-1 and
Strongyloidiasis Co-infection Is Associated with Reduced
IL-5 Responses to Strongyloides stercoralis Antigen
1,2 1 1,2 3 1
Martin Montes *, Cesar Sanchez , Kristien Verdonck , Jordan E. Lake , Elsa Gonzalez , Giovanni
1 1 4 5 1 5
Lopez , Angelica Terashima , Thomas Nolan , Dorothy E. Lewis , Eduardo Gotuzzo , A. Clinton White Jr.
1 Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, 2 Division of Infectious Diseases, Department of Internal
Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America, 3 Virology Unit, Department of Microbiology, Institute of Tropical Medicine,
Antwerp, Belgium, 4 Department of Medicine, Division of Infectious Diseases, University of California at Los Angeles, Los Angeles, California, United States of America,
5 Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
Abstract
Background: Human strongyloidiasis varies from a chronic but limited infection in normal hosts to hyperinfection in
patients treated with corticosteroids or with HTLV-1 co-infection. Regulatory T cells dampen immune responses to
infections. How human strongyloidiasis is controlled and how HTLV-1 infection affects this control are not clear. We
hypothesize that HTLV-1 leads to dissemination of Strongyloides stercoralis infection by augmenting regulatory T cell
numbers, which in turn down regulate
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