原创力文档regulation of zebrafish skeletogenesis by ext2dackel and papst1pinscher调节斑马鱼skeletogenesis ext2dackel和papst1pinscher.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
regulation of zebrafish skeletogenesis by ext2dackel and papst1pinscher调节斑马鱼skeletogenesis ext2dackel和papst1pinscher
Regulation of Zebrafish Skeletogenesis by ext2/dackel
and papst1/pinscher
´ ´ 1,2 1,2 3 4,5
Aurelie Clement , Malgorzata Wiweger , Sophia von der Hardt , Melissa A. Rusch , Scott B.
Selleck4,5, Chi-Bin Chien6,7, Henry H. Roehl1,2*
1 MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom, 2 Department of Biomedical Science, University of Sheffield,
¨
Sheffield, United Kingdom, 3 Abteilung Genetik, MPI fur Entwicklungsbiologie, Tuebingen, Germany, 4 Department of Pediatrics, University of Minnesota, Minneapolis,
Minnesota, United States of America, 5 Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of
America, 6 Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, United States of America, 7 Brain Institute, University of Utah, Salt Lake City,
Utah, United States of America
Abstract
Mutations in human Exostosin genes (EXTs) confer a disease called Hereditary Multiple Exostoses (HME) that affects 1 in
50,000 among the general population. Patients with HME have a short stature and develop osteochondromas during
childhood. Here we show that two zebrafish mutants, dackel (dak) and pinscher (pic), have cartilage defects that strongly
resemble those seen in HME patients. We have previously determined that dak encodes zebrafish Ext2. Positional cloning of
pic reveals that it encodes a sulphate transporter required for sulphation of glycans (Papst1). We show that although both
dak and pic are required during cartilage morphogenesis, they are dispensable for chondrocyte and pe
您可能关注的文档
- reducing the mysteries of sulfur metabolism减少硫代谢的奥秘.pdf
- reducing plasmodium falciparum malaria transmission in africa a model-based evaluation of intervention strategies在非洲减少恶性疟原虫疟疾传播干预策略的基于模型的评价.pdf
- reducing the impact of the next influenza pandemic using household-based public health interventions减少下一次流感大流行的影响使用分户的公共卫生干预措施.pdf
- reduction and return of infectious trachoma in severely affected communities in ethiopia减少和严重影响社区感染沙眼的回归在埃塞俄比亚.pdf
- reduction of dopamine level enhances the attractiveness of male drosophila to other males减少多巴胺水平提高雄性果蝇其他雄性的吸引力.pdf
- reduction of dilp2 in drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among dilps减少dilp2果蝇寿命的代谢表型分类揭示dilps之间的冗余和补偿.pdf
- reduction of malaria transmission to anopheles mosquitoes with a six-dose regimen of co-artemether减少疟疾传播按蚊与co-artemether six-dose方案.pdf
- reduction in learning rates associated with anterograde interference results from interactions between different timescales in motor adaptation减少学习利率与顺行干扰从电机适应不同时间尺度之间的相互作用的结果.pdf
- reduction of canine plasminogen leads to an expanded molecule which precipitates减少宠物纤溶酶原导致扩大分子物沉淀.pdf
- reduction of nadph-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of williams-beuren syndrome减少nadph-oxidase活动改善心血管表型williams-beuren综合征小鼠模型.pdf
- regulators of awc-mediated olfactory plasticity in caenorhabditis elegans监管者awc-mediated嗅觉可塑性的线虫.pdf
- regulatory elements within the prodomain of falcipain-2, a cysteine protease of the malaria parasite plasmodium falciparum监管元素falcipain-2 prodomain内,半胱氨酸蛋白酶的恶性疟原虫.pdf
- regulatory effects of ifn-β on the development of experimental autoimmune uveoretinitis in b10riii mice监管的影响ifn-βb10riii小鼠实验性自身免疫性uveoretinitis的发展.pdf
- regulatory network analyses reveal genome-wide potentiation of lif signaling by glucocorticoids and define an innate cell defense response监管网络分析揭示基因组势差现象制药业信号由糖皮质激素和定义一个天生的细胞防御反应.pdf
- regulatory network structure as a dominant determinant of transcription factor evolutionary rate监管网络结构作为转录因子进化速率的主要因素.pdf
- regulatory t cell expansion in htlv-1 and strongyloidiasis co-infection is associated with reduced il-5 responses to strongyloides stercoralis antigen调节性t细胞扩张htlv 1和类圆线虫病合并感染与降低il-5反应类圆线虫属stercoralis抗原.pdf
- regulatory cross-talk links vibrio cholerae chromosome ii replication and segregation监管相声链接霍乱弧菌ii号染色体复制和隔离.pdf
- regulation of septin dynamics by the saccharomyces cerevisiae lysine acetyltransferase nua4监管septin动力学的酿酒酵母赖氨酸乙酰转移酶nua4.pdf
- regulatory roles of cytokinins and cytokinin signaling in response to potassium deficiency in arabidopsis监管角色的细胞分裂素和细胞分裂素信号响应在拟南芥缺钾.pdf
- regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning监管机构的3 g蛋白信号调节wnt5b钙动力学和体节模式.pdf
文档评论（0）