原创力文档residential dampness and molds and the risk of developing asthma a systematic review and meta-analysis住宅潮湿和霉菌和患哮喘的风险系统回顾和荟萃分析.pdfVIP
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residential dampness and molds and the risk of developing asthma a systematic review and meta-analysis住宅潮湿和霉菌和患哮喘的风险系统回顾和荟萃分析
Residential Dampness and Molds and the Risk of
Developing Asthma: A Systematic Review and Meta-
Analysis
1 1,2 1,3 1,2
Reginald Quansah , Maritta S. Jaakkola , Timo T. Hugg , Sirpa A. M. Heikkinen , Jouni J.
K. Jaakkola1,3*
1 Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland, 2 Respiratory Medicine Unit, Institute of Clinical Medicine, University of
Oulu and Oulu University Hospital, Oulu, Finland, 3 Institute of Health Sciences, University of Oulu, Oulu, Finland
Abstract
Context: Studies from different geographical regions have assessed the relations between indoor dampness and mold
problems and the risk of asthma, but the evidence has been inconclusive.
Objective: To assess the relations between indicators of indoor dampness and mold problems and the risk of developing
new asthma, and to investigate whether such relations differ according to the type of exposure.
Data sources: A systematic literature search of PubMed database from 1990 through March 2012 and the reference lists of
recent reviews and of relevant articles identified in our search.
Study selection: Cohort/longitudinal and incident case-control studies assessing the relation between mold/dampness and
new asthma were included.
Data extraction: Three authors independently evaluated eligible articles and extracted relevant information using a
structured form.
Synthesis: Sixteen studies were included: 11 cohort and 5 incident case-control studies. The summary effect estimates (EE)
based on the highest and lowest estimates for the relation between any exposure and onset of asthma were 1.50 (95%
confidence interval [CI] 1.25–1.80, random-effects model, Q-statis
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