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reshaping of bulbar odor response by nasal flow rate in the rat重塑球鼻气味反应流量的老鼠
Reshaping of Bulbar Odor Response by Nasal Flow Rate
in the Rat
´
Emmanuelle Courtiol*, Corine Amat, Marc Thevenet, Belkacem Messaoudi, Samuel Garcia, Nathalie
Buonviso
´
Universite Lyon 1, Centre National de la Recherche Scientifique, UMR 5020 Neurosciences Sensorielles, Comportement, Cognition, Lyon, France
Abstract
Background: The impact of respiratory dynamics on odor response has been poorly studied at the olfactory bulb level.
However, it has been shown that sniffing in the behaving rodent is highly dynamic and varies both in frequency and flow
rate. Bulbar odor response could vary with these sniffing parameter variations. Consequently, it is necessary to understand
how nasal airflow can modify and shape odor response at the olfactory bulb level.
Methodology and Principal Findings: To assess this question, we used a double cannulation and simulated nasal airflow
protocol on anesthetized rats to uncouple nasal airflow from animal respiration. Both mitral/tufted cell extracellular unit
activity and local field potentials (LFPs) were recorded. We found that airflow changes in the normal range were sufficient to
substantially reorganize the response of the olfactory bulb. In particular, cellular odor-evoked activities, LFP oscillations and
spike phase-locking to LFPs were strongly modified by nasal flow rate.
Conclusion: Our results indicate the importance of reconsidering the notion of odor coding as odor response at the bulbar
level is ceaselessly modified by respiratory dynamics.
´
Citation: Courtiol E, Amat C, Thevenet M, Messaoudi B, Garcia S, et al. (2011) Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat. PLoS ONE 6(1):
e16445. doi:10.1371/journal.pone.0016445
Editor: Steven Barnes, Dalhousie University, Canada
Receiv
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