原创力文档residual antimalarials in malaria patients from tanzania – implications on drug efficacy assessment and spread of parasite resistance剩余抗疟疾病人从坦桑尼亚u2014u2014影响药物疗效评估和传播疟疾寄生虫对青蒿素的耐药性.pdfVIP
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residual antimalarials in malaria patients from tanzania – implications on drug efficacy assessment and spread of parasite resistance剩余抗疟疾病人从坦桑尼亚u2014u2014影响药物疗效评估和传播疟疾寄生虫对青蒿素的耐药性
Residual Antimalarials in Malaria Patients from
Tanzania – Implications on Drug Efficacy Assessment
and Spread of Parasite Resistance
1 2 2 3 3
Eva Maria Hodel , Abdunoor Mulokozi Kabanywanyi , Aggrey Malila , Boris Zanolari , Thomas Mercier ,
1 3 4 3 1,5
Hans-Peter Beck , Thierry Buclin , Piero Olliaro , Laurent Arthur Decosterd , Blaise Genton *
1 Swiss Tropical Institute, Basel, Switzerland, 2 Ifakara Health Institute, Dar es Salaam and Ifakara, Tanzania, 3 Division of Clinical Pharmacology, Department de Medicine,
University Hospital and University of Lausanne, Lausanne, Switzerland, 4 UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical
Diseases (TDR), Geneva, Switzerland, 5 Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
Abstract
Background: Repeated antimalarial treatment for febrile episodes and self-treatment are common in malaria-endemic areas.
The intake of antimalarials prior to participating in an in vivo study may alter treatment outcome and affect the
interpretation of both efficacy and safety outcomes. We report the findings from baseline plasma sampling of malaria
patients prior to inclusion into an in vivo study in Tanzania and discuss the implications of residual concentrations of
antimalarials in this setting.
Methods and Findings: In an in vivo study conducted in a rural area of Tanzania in 2008, baseline plasma samples from
patients reporting no antimalarial intake with
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