reproductive intentions and outcomes among women on antiretroviral therapy in rural uganda a prospective cohort study女性生殖意图和结果对乌干达农村抗逆转录病毒治疗的前瞻性队列研究.pdfVIP

Reproductive Intentions and Outcomes among Women on Antiretroviral Therapy in Rural Uganda: A Prospective Cohort Study 1,2 1 1,3 1,2 1 1 Jaco Homsy *, Rebecca Bunnell , David Moore , Rachel King , Samuel Malamba , Rose Nakityo , 2 1 1 David Glidden , Jordan Tappero , Jonathan Mermin 1 Centers for Disease Control and Prevention (CDC), Global AIDS Program, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Entebbe, Uganda, 2 Global Health Sciences, Prevention and Public Health Group, University of California San Francisco, San Francisco, California, United States of America, 3 British Columbia Centre for Excellence in HIV/AIDS, University of British Columbia, Vancouver, Canada Abstract Background: Antiretroviral therapy (ART) may influence the biological, social and behavioral determinants of pregnancy in HIV-infected women. However, there are limited longitudinal data on the reproductive intentions and outcomes among women on ART in Africa. Methodology /Principal Findings: Using a prospective cohort design, we analyzed trends in desire for children and predictors of pregnancy among a cohort of 733 HIV-infected women in rural Uganda who initiated ART between May 2003 and May 2004 and were followed up in their homes until June 2006. Women answered in-depth social and behavioral questionnaires administered every quarter in year 1 after initiating ART, and every 6 to 12 months thereafter. Use of family planning methods was assessed at 18 and 24 months after starting ART. We tested for non-constant pregnancy incidence by using a shape parameter test from the Weibull distribution. We modeled