原创力文档robust antigen specific th17 t cell response to group a streptococcus is dependent on il-6 and intranasal route of infection健壮的a群链球菌抗原特异性th17 t细胞反应取决于il - 6和鼻内感染的途径.pdfVIP
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robust antigen specific th17 t cell response to group a streptococcus is dependent on il-6 and intranasal route of infection健壮的a群链球菌抗原特异性th17 t细胞反应取决于il - 6和鼻内感染的途径
Robust Antigen Specific Th17 T Cell Response to Group A
Streptococcus Is Dependent on IL-6 and Intranasal Route
of Infection
1. 2. 3 2
Thamotharampillai Dileepan *, Jonathan L. Linehan , James J. Moon , Marion Pepper , Marc K.
Jenkins2, Patrick P. Cleary1
1 Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America, 2 Department of Microbiology-Center for Immunology,
Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America, 3 The Center for Immunology Inflammatory Diseases, Division of
Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Cambridge, Massachusetts, United States of America
Abstract
Group A streptococcus (GAS, Streptococcus pyogenes) is the cause of a variety of clinical conditions, ranging from pharyngitis
to autoimmune disease. Peptide-major histocompatibility complex class II (pMHCII) tetramers have recently emerged as a
highly sensitive means to quantify pMHCII-specific CD4+ helper T cells and evaluate their contribution to both protective
immunity and autoimmune complications induced by specific bacterial pathogens. In lieu of identifying an
immunodominant peptide expressed by GAS, a surrogate peptide (2W) was fused to the highly expressed M1 protein
on the surface of GAS to allow in-depth analysis of the CD4+ helper T cell response in C57BL/6 mice that express the I-Ab
b +
MHCII molecule. Following intranasal inoculation with GAS-2W, antigen-experienced 2W:I-A -speci
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