retrospective analysis for genetic improvement of hip joints of cohort labrador retrievers in the united states 1970–2007回顾性分析髋关节的遗传改良群体拉布拉多在美国1970 - 2007.pdfVIP

Retrospective Analysis for Genetic Improvement of Hip Joints of Cohort Labrador Retrievers in the United States: 1970–2007 1. 1. 2 3 4 5 Yali Hou , Yachun Wang , George Lust , Lan Zhu , Zhiwu Zhang *, Rory J. Todhunter 1 College of Animal Science Technology, China Agricultural University, Beijing, China, 2 Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America, 3 Department of Statistics, Oklahoma State University, Stillwater, Oklahoma, United States of America, 4 Institute for Genomic Diversity, Cornell University, Ithaca, New York, United States of America, 5 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America Abstract Background: Canine Hip Dysplasia (CHD) is a common inherited disease that affects dog wellbeing and causes a heavy financial and emotional burden to dog owners and breeders due to secondary hip osteoarthritis. The Orthopedic Foundation for Animals (OFA) initiated a program in the 1960’s to radiograph hip and elbow joints and release the OFA scores to the public for breeding dogs against CHD. Over last four decades, more than one million radiographic scores have been released. Methodology/Principal Findings: The pedigrees in the OFA database consisted of 258,851 Labrador retrievers, the major breed scored by the OFA (25% of total records). Of these, 154,352 dogs had an OFA hip score reported between 1970 and 2007. The rest of the dogs (104,499) were the ancestors of the 154,352 dogs to link the pedigree relationships. The OFA hip score is based on a 7-point scale with the best ranked as 1 (excellent) and the worst hip dy