renal function is related to severity of coronary artery calcification in elderly persons the rotterdam study肾功能严重冠状动脉钙化有关老年人的鹿特丹学习.pdfVIP

Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study 1 1 1 2 Abdelilah el Barzouhi *, Suzette Elias-Smale , Abbas Dehghan , Rozemarijn Vliegenthart-Proenc¸a , 2 1 1 Matthijs Oudkerk , Albert Hofman , Jacqueline C. M. Witteman 1 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, 2 Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Abstract Background: Coronary artery calcification (CAC) has been proposed to be the underlying mechanism of the increased risk of coronary heart disease with reductions in glomerular filtration rate (GFR). Since renal function diminishes with aging we examined the association between GFR and CAC in the Rotterdam Study, a population-based study of elderly individuals. Methods: The study was performed in 1703 subjects without a history of coronary heart disease. GFR was estimated using the modification of diet in renal disease equation. We used analysis of covariance to test for mean differences in CAC between GFR tertiles. Results: The mean CAC scores in the middle and lowest GFR tertile did not significantly differ from the mean CAC score in the highest GFR tertile (geometric mean CAC score 4.1 and 4.3 vs 4.2). In a multivariable model the mean CAC score did also not differ between the GFR tertiles. As the interaction term between age and GFR was significant (P = 0.037), we divided the population in two age categories based on median age of 70 years. Below 70 years, the mean CAC scores did not differ between the GFR tertiles. Above median age, mean C