renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-na？ve patients with hiv infection替诺福韦-肾功能下降超过abacavir-based抗逆转录病毒疗法在身体健康体重treatment-na ve艾滋病毒感染患者.pdfVIP

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renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-na？ve patients with hiv infection替诺福韦-肾功能下降超过abacavir-based抗逆转录病毒疗法在身体健康体重treatment-na ve艾滋病毒感染患者.pdf

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renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-na？ve patients with hiv infection替诺福韦-肾功能下降超过abacavir-based抗逆转录病毒疗法在身体健康体重treatment-na ve艾滋病毒感染患者

Renal Function Declines More in Tenofovir- than Abacavir-Based Antiretroviral Therapy in Low-Body ¨ Weight Treatment-Naıve Patients with HIV Infection 1,4 1,4 3 1 2 Takeshi Nishijima , Hiroyuki Gatanaga *, Hirokazu Komatsu , Kunihisa Tsukada , Takuro Shimbo , 1 1,4 1 1 1 1 Takahiro Aoki , Koji Watanabe , Ei Kinai , Haruhito Honda , Junko Tanuma , Hirohisa Yazaki , Miwako 1 1 1 1,4 Honda , Katsuji Teruya , Yoshimi Kikuchi , Shinichi Oka 1 AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan, 2 Department of Clinical Research and Informatics, International Clinical Research Center, National Center for Global Health and Medicine, Tokyo, Japan, 3 Department of Community Care, Saku Central Hospital, Nagano, Japan, 4 Center for AIDS Research, Kumamoto University, Kumamoto, Japan Abstract Objective: To compare the rate of decline of renal function in tenofovir- and abacavir-based antiretroviral therapy (ART) in ¨ low-body weight treatment-naıve patients with HIV infection. Design: We conducted a single-center retrospective cohort study of 503 Japanese patients who commenced on either tenofovir- or abacavir-based initial ART. Methods: The incidence of renal dysfunction, defined as more than 25% fall in estimated glomerular filtration rate (eGFR) from the baseline, was determined in each group. The effect of tenofovir on renal dysf