role of cebpβ transcription factor in adult hippocampal neurogenesiscebpβ转录因子在成人海马神经发生的作用.pdfVIP

Role of C/EBPb Transcription Factor in Adult Hippocampal Neurogenesis 1,2¤ 1,2 1,2 3 Marta Cortes-Canteli , Diana Aguilar-Morante , Marina Sanz-SanCristobal , Diego Megias , Angel Santos4, Ana Perez-Castillo1,2* 1 Instituto de Investigaciones Biomedicas ‘‘Alberto Sols’’, Consejo Superior de Investigaciones Cientificas-Universidad Autonoma de Madrid, Madrid, Spain, 2 Centro de ´ ´ Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain, 3 Centro Nacional de Investigaciones Oncologicas, Madrid, Spain, 4 Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain Abstract Background: The dentate gyrus of the hippocampus is one of the regions in which neurogenesis takes place in the adult brain. We have previously demonstrated that CCAAT/enhancer binding protein b (C/EBPb) is expressed in the granular layer of the dentate gyrus of the adult mouse hippocampus. Taking into account the important role of C/EBPb in the consolidation of long term memory, the fact that newborn neurons in the hippocampus contribute to learning and memory processes, and the role of this transcription factor, previously demonstrated by our group, in regulating neuronal differentiation, we speculated that this transcription factor could regulate stem/progenitor cells in this region of the brain. Methodology/Principal Findings: Here, we show, using C/EBPb knockout mice, that C/EBPb expression is observed in the subset of newborn cells that proliferate in the hippocampus of the adult brain. Mice lacking C/EBPb present reduced survival of newborn