原创力文档role of intestinal bacteria in gliadin-induced changes in intestinal mucosa study in germ-free rats肠道细菌在gliadin-induced肠道粘膜的变化研究无菌老鼠.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
role of intestinal bacteria in gliadin-induced changes in intestinal mucosa study in germ-free rats肠道细菌在gliadin-induced肠道粘膜的变化研究无菌老鼠
Role of Intestinal Bacteria in Gliadin-Induced Changes in
Intestinal Mucosa: Study in Germ-Free Rats
1 2 1 1 1
Jana Cinova *, Giada De Palma , Renata Stepankova , Olga Kofronova , Miloslav Kverka , Yolanda
Sanz2, Ludmila Tuckova1
1 Department of Immunology, Institute of Microbiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic, 2 Microbial Ecophysiology and
Nutrition Group, Institute of Agrochemistry and Food Technology (IATA), National Spanish Research Council (CSIC), Valencia, Spain
Abstract
Background and Aims: Celiac disease (CD) is a chronic inflammatory disorder of the small intestine that is induced by
dietary wheat gluten proteins (gliadins) in genetically predisposed individuals. The overgrowth of potentially pathogenic
bacteria and infections has been suggested to contribute to CD pathogenesis. We aimed to study the effects of gliadin and
various intestinal bacterial strains on mucosal barrier integrity, gliadin translocation, and cytokine production.
Methodology/Principal Findings: Changes in gut mucosa were assessed in the intestinal loops of inbred Wistar-AVN rats
that were reared under germ-free conditions in the presence of various intestinal bacteria (enterobacteria and bifidobacteria
isolated from CD patients and healthy children, respectively) and CD-triggering agents (gliadin and IFN-c) by histology,
scanning electron microscopy, immunofluorescence, and a rat cytokine antibody array. Adhesion of the bacterial strains to
the IEC-6 rat cell line was evaluated in vitro. Gliadin fragments alone or together with the proinflammatory cytokine
interferon (
您可能关注的文档
- revisiting the myths of protein interior studying proteins with mass-fractal hydrophobicity-fractal and polarizability-fractal dimensions回顾蛋白质内部的神话研究蛋白质与mass-fractal hydrophobicity-fractal和polarizability-fractal维度.pdf
- reviving the african wolf canis lupus lupaster in north and west africa a mitochondrial lineage ranging more than 6,000 km wide振兴非洲狼狼豺在非洲北部和西部一个线粒体血统范围超过6000公里宽.pdf
- revisiting the design of phase iii clinical trials of antimalarial drugs for uncomplicated plasmodium falciparum malaria回顾iii期临床试验的设计无并发症恶性疟原虫疟疾的抗疟药.pdf
- revolutionizing clinical microbiology laboratory organization in hospitals with in situ point-of-care在医院中对临床微生物实验室组织原位医疗点.pdf
- revised lithostratigraphy of the sonsela member (chinle formation, upper triassic) in the southern part of petrified forest national park, arizona修订后的岩相层序sonsela成员(chinle形成,上三叠纪)石化林国家公园的南部,亚利桑那州.pdf
- r-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids氟比洛芬酯减少在啮齿动物通过恢复内源性大麻类神经性疼痛.pdf
- rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of mcp-1rgs2介导pro-angiogenic骨髓衍生功能抑制肿瘤细胞微环境通过upregulation mcp-1.pdf
- rhabdomyosarcomas in aging aj mice横纹肌肉瘤在老化aj老鼠.pdf
- rhamnose-inducible gene expression in listeria monocytogenes单核细胞增多性李斯特氏菌rhamnose-inducible基因表达.pdf
- rhesus factor modulation of effects of smoking and age on psychomotor performance, intelligence, personality profile, and health in czech soldiersrh因子调制的吸烟和年龄对精神运动性能的影响,智力、个性特征和健康在捷克士兵.pdf
- role of human-mediated dispersal in the spread of the pinewood nematode in china人工中介传播在松木的传播线虫在中国.pdf
- role of kras status in patients with metastatic colorectal cancer receiving first-line chemotherapy plus bevacizumab a ttd group cooperative study喀斯特作用状态转移性结直肠癌患者接受一线化疗加贝伐单抗运输大亨小组合作学习.pdf
- role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins人类sec63在调制多跨膜蛋白的稳态水平.pdf
- role of hsp70 atpase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with nefshsp70 atp酶的作用域的内在动力和序列进化使其功能与nef的交互.pdf
- role of interferon gamma release assay in active tb diagnosis among hiv infected individualsγ干扰素释放试验在诊断活动性结核病在艾滋病毒感染者.pdf
- role of kcnma1 in breast cancerkcnma1在乳腺癌的作用.pdf
- role of mechanical factors in the morphology of the primate cerebral cortex力学因素在灵长类动物大脑皮层的形态.pdf
- role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in il-10-deficient mice肥大细胞在炎症性肠病中的作用和炎症反应的结直肠肿瘤il-10-deficient老鼠.pdf
- role of microrna-182 in posterior uveal melanoma regulation of tumor development through mitf, bcl2 and cyclin d2作用的微rna - 182通过mitf后葡萄膜黑色素瘤肿瘤发展的监管,bcl2和细胞周期蛋白d2.pdf
- role of lipids in spheroidal high density lipoproteins角色球状高密度脂蛋白的脂质.pdf
文档评论（0）