revisiting the design of phase iii clinical trials of antimalarial drugs for uncomplicated plasmodium falciparum malaria回顾iii期临床试验的设计无并发症恶性疟原虫疟疾的抗疟药.pdfVIP
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revisiting the design of phase iii clinical trials of antimalarial drugs for uncomplicated plasmodium falciparum malaria回顾iii期临床试验的设计无并发症恶性疟原虫疟疾的抗疟药
Policy Forum
Revisiting the Design of Phase III Clinical Trials
of Antimalarial Drugs for Uncomplicated
Plasmodium falciparum Malaria
Steffen Borrmann*, Tim Peto, Robert W. Snow, Win Gutteridge, Nicholas J. White
n 2002, Plasmodium falciparum Summary Points the most relevant property of a new
caused at least 0.5 billion antimalarial drug [9,15]. In other
uncomplicated clinical attacks of words, in phase III trials, should we ask:
I
priority for antimalarial treatment; its
malaria worldwide, particularly in non-
measurement as primary endpoint
immune young children living in Africa
[1]. Because inadequately treated in phase III trials provides consistent Funding: SB is funded by a German Research
estimates of the antiparasitic effect of a Foundation (DFG) Junior Group grant (SFB 544, A7).
uncomplicated P. falciparum malaria new regimen. RWS and NJW are Wellcome Trust Principal Research
can progress rapidly to life-threatening Fellows. SB and RWS acknowledge the support of
severe malaria [2,3], mortality from the Kenyan Medical Research Institute. NJW is part
P. falciparum in Africa doubled during episodes by slowly eliminated new of the Mahidol Oxford Tropical Medicine Research
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