reporting methods of blinding in randomized trials assessing nonpharmacological treatments报告的眩目的随机试验和评估非药物治疗方法.pdfVIP

PLoS MEDICINE Reporting Methods of Blinding in Randomized Trials Assessing Nonpharmacological Treatments 1,2,3* 1,2,3 1,2,3 4,5 ´ 6 Isabelle Boutron , Lydia Guittet , Candice Estellat , David Moher , Asbjørn Hrobjartsson , Philippe Ravaud1,2,3 ´ ´ ˆ ´ ´ 1 INSERM, U738, Paris, France, 2 Universite Paris 7, UFR de Medecine, Paris, France, 3 AP-HP, Hopital Bichat, Departement d’Epidemiologie, Biostastique et Recherche Clinique, Paris, France, 4 Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Canada, 5 Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada, 6 Nordic Cochrane Centre, Rigshospitalet, Copenhagen, Denmark Funding: DM is funded, in part, by a A B S T R A C T University of Ottawa Research Chair. The funders had no role in study design, data collection and analysis, decision to publish, or preparation Background of the manuscript. Blinding is a cornerstone of treatment evaluation. Blinding is more difficult to obtain in trials Competing Interests: The authors assessing nonpharmacological treatment and frequently relies on ‘‘creative’’ (nonstandard) have declared that no competing methods. The purpose of this study was to systematically describe the strategies used to obtain interests exist. blinding in a sample of randomized controlled t