原创力文档regulation of lifespan, metabolism, and stress responses by the drosophila sh2b protein, lnk寿命调节、代谢和应激反应的果蝇sh2b蛋白质,lnk.pdfVIP
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regulation of lifespan, metabolism, and stress responses by the drosophila sh2b protein, lnk寿命调节、代谢和应激反应的果蝇sh2b蛋白质,lnk
Regulation of Lifespan, Metabolism, and Stress
Responses by the Drosophila SH2B Protein, Lnk
1 2 3 1 1 2
Cathy Slack , Christian Werz , Daniela Wieser , Nazif Alic , Andrea Foley , Hugo Stocker , Dominic J.
4 3 2 1
Withers , Janet M. Thornton , Ernst Hafen , Linda Partridge *
1 Institute of Healthy Ageing, Department of Genes, Evolution, and Environment, University College London, London, United Kingdom, 2 ETH Zurich, Institute of
Molecular Systems Biology, Zurich, Switzerland, 3 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, 4 Centre for
Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
Abstract
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor
proteins, the SH2B proteins. As adaptors, they lack catalytic activity but contain several protein–protein interaction domains,
thus playing a critical role in signal transduction from receptor tyrosine kinases to form protein networks. Physiological
studies of SH2B function in mammals have produced conflicting data. However, a recent study in Drosophila has shown that
Lnk is an important regulator of the insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway during growth,
functioning in parallel to the insulin receptor substrate, Chico. As this pathway also has an evolutionary conserved role in
the determination of organism lifespan, we investigated whether Lnk is required for normal lifespan in Drosophila.
Phenotypic analysis of mutants for Lnk reveal
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