regulation of peripheral inflammation by spinal p38 map kinase in rats调节周围炎症大鼠脊髓p38激酶地图.pdfVIP

PLoS MEDICINE Regulation of Peripheral Inflammation by Spinal p38 MAP Kinase in Rats 1 2 1 2 1 1 David L. Boyle , Toni L. Jones , Deepa Hammaker , Camille I. Svensson , Sanna Rosengren , Salvatore Albani , 2 1* Linda Sorkin , Gary S. Firestein 1 Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America, 2 Department of Anesthesiology, University of California San Diego School of Medicine, La Jolla, California, United States of America Funding: This work was supported A B S T R A C T by grants from the Arthritis Foundation (GSF) and the National Institute of Arthritis and Musculoskeletal, and Skin Diseases Background (RO1 AR47825) (GSF).The funders had no role in study design, data Somatic afferent input to the spinal cord from a peripheral inflammatory site can modulate collection and analysis, decision to the peripheral response. However, the intracellular signaling mechanisms in the spinal cord publish, or preparation of the that regulate this linkage have not been defined. Previous studies suggest spinal cord p38 manuscript. mitogen-activated protein (MAP) kinase and cytokines participate in nociceptive behavior. We Competing Interests: The authors therefore determined whether these pathways also regulate peripheral inflammation