reduced connectivity in the self-processing network of schizophrenia patients with poor insight减少self-processing网络的连通性差的精神分裂症患者洞察力.pdfVIP

Reduced Connectivity in the Self-Processing Network of Schizophrenia Patients with Poor Insight 1,2 1,3 1,3 1 Edith J. Liemburg *, Lisette van der Meer , Marte Swart , Branislava Curcic-Blake , 3 1,2,3 ´ 1,4 Richard Bruggeman , Henderikus Knegtering , Andre Aleman 1 Department of Neuroscience, University Medical Center Groningen and BCN NeuroImaging Center, University of Groningen, Groningen, The Netherlands, 2 Rob Giel Research Center, University Medical Center Groningen, Groningen, The Netherlands, 3 Lentis, Center for Mental Healthcare, Groningen, The Netherlands, 4 Department of Psychology, University of Groningen, Groningen, The Netherlands Abstract Lack of insight (unawareness of illness) is a common and clinically relevant feature of schizophrenia. Reduced levels of self- referential processing have been proposed as a mechanism underlying poor insight. The default mode network (DMN) has been implicated as a key node in the circuit for self-referential processing. We hypothesized that during resting state the DMN network would show decreased connectivity in schizophrenia patients with poor insight compared to patients with good insight. Patients with schizophrenia were recruited from mental health care centers in the north of the Netherlands and categorized in groups having good insight (n = 25) or poor insight (n = 19). All subjects underwent a resting state fMRI scan. A healthy control group (n = 30) was used as a reference. Functional connectivity of the anterior and posterior part of the DMN, identified using Independent Component Analysis, was compared between groups. Patients with poo