reduced exercise tolerance and pulmonary capillary recruitment with remote secondhand smoke exposure减少运动耐量和肺毛细血管招聘与远程接触二手烟.pdfVIP

Reduced Exercise Tolerance and Pulmonary Capillary Recruitment with Remote Secondhand Smoke Exposure 1,3,4 5 6 1,4 1,2,3 Mehrdad Arjomandi *, Thaddeus Haight , Nasrat Sadeghi , Rita Redberg , Warren M. Gold 1 University of California San Francisco Flight Attendants Medical Research Institute Center of Excellence, San Francisco, California, United States of America, 2 Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America, 3 Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, 4 San Francisco Veterans Affairs Medical Center, San Francisco, California, United States of America, 5 School of Public Health, University of California Berkeley, Berkeley, California, United States of America, 6 Radboud University Medical Center, Nijmegen, Netherlands Abstract Rationale: Flight attendants who worked on commercial aircraft before the smoking ban in flights (pre-ban FAs) were exposed to high levels of secondhand smoke (SHS). We previously showed never-smoking pre-ban FAs to have reduced diffusing capacity (Dco) at rest. _ Methods: To determine whether pre-ban FAs increase their Dco and pulmonary blood flow (QQc) during exercise, we administered a symptom-limited supine-posture progressively increasing cycle exercise test to determine the maximum _