原创力文档reduced costs for staphylococcus aureus carriers treated prophylactically with mupirocin and chlorhexidine in cardiothoracic and orthopaedic surgery降低成本为金黄色葡萄球菌运营商采取预防性治疗莫匹罗星和洗必泰心胸和骨科手术.pdfVIP
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reduced costs for staphylococcus aureus carriers treated prophylactically with mupirocin and chlorhexidine in cardiothoracic and orthopaedic surgery降低成本为金黄色葡萄球菌运营商采取预防性治疗莫匹罗星和洗必泰心胸和骨科手术
Reduced Costs for Staphylococcus aureus Carriers
Treated Prophylactically with Mupirocin and
Chlorhexidine in Cardiothoracic and Orthopaedic
Surgery
1 . 2. 3 1,4
Miranda M. L. van Rijen * , Lonneke G. M. Bode , Diane A. Baak , Jan A. J. W. Kluytmans ,
Margreet C. Vos2
1 Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands, 2 Department of Medical Microbiology and Infectious Diseases, Erasmus
University Medical Centre, Rotterdam, The Netherlands, 3 Business Information Centre, Amphia Hospital, Breda, The Netherlands, 4 Department of Medical Microbiology
and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
Abstract
Background: A multi centre double-blind randomised-controlled trial (M-RCT), carried out in the Netherlands in 2005–2007,
showed that hospitalised patients with S. aureus nasal carriage who were treated prophylactically with mupirocin nasal
ointment and chlorhexidine gluconate medicated soap (MUP-CHX), had a significantly lower risk of health-care associated
S. aureus infections than patients receiving placebo (3.4% vs. 7.7%, RR 0.42, 95% CI 0.23–0.75). The objective of the present
study was to determine whether treatment of patients undergoing elective cardiothoracic or orthopaedic surgery with
MUP-CHX (screen-and-treat strategy) affected the costs of patient care.
Methods: We compared hospital costs of patients undergoing cardiothoracic or orthopaedic surgery (n = 415) in one of the
participating centres of the M-RCT. Data from the ‘Planning and Control’ department were used to calculate total hospital
costs of the patients. Total costs were calculated including nursing days, costs of s
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