reproducibility and respiratory function correlates of exhaled breath fingerprint in chronic obstructive pulmonary disease再现性和呼吸功能相关的呼出气息指纹在慢性阻塞性肺疾病.pdfVIP

Reproducibility and Respiratory Function Correlates of Exhaled Breath Fingerprint in Chronic Obstructive Pulmonary Disease 1,2 3 1 3,4 Raffaele Antonelli Incalzi , Giorgio Pennazza , Simone Scarlata *, Marco Santonico , 3 1 1 4 Massimo Petriaggi , Domenica Chiurco , Claudio Pedone , Arnaldo D’Amico ` 1 Chair of Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio-Medico University, Rome, Italy, 2 San Raffaele-Cittadella della Carita Foundation, Taranto, Italy, 3 Center for Integrated Research – CIR, Unit of Electronics for Sensor Systems, Campus Bio-Medico University, Rome, Italy, 4 Department of Electronic Engineering, University of Rome ‘‘Tor Vergata’’, Rome, Italy Abstract Background: The electronic nose (e nose) provides distinctive breath fingerprints for selected respiratory diseases. Both reproducibility and respiratory function correlates of breath fingerprint are poorly known. Objectives: To measure reproducibility of breath fingerprints and to assess their correlates among respiratory function indexes in elderly healthy and COPD subjects. Method: 25 subjects (5 COPD patients for each GOLD stage and 5 healthy controls) over 65 years underwent e-nose study through a seven sensor system and respiratory function tests at times 0, 7, and 15 days. Reproducibility of the e nose pattern was computed. The correlation between volatile organic compound