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runx3 has an oncogenic role in head and neck cancerrunx3在头部和颈部癌症有致癌的作用
RUNX3 Has an Oncogenic Role in Head and Neck Cancer
1 1 1 2 3 3
Takaaki Tsunematsu , Yasusei Kudo *, Shinji Iizuka , Ikuko Ogawa , Tsuyoshi Fujita , Hidemi Kurihara ,
4 1
Yoshimitsu Abiko , Takashi Takata *
1 Division of Frontier Medical Science, Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima,
Japan, 2 Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan, 3 Division of Frontier Medical Science, Department of Periodontal Medicine,
Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan, 4 Department of Biochemistry, School of Dentistry at Matsudo, Nihon University, Tokyo,
Japan
Abstract
Background: Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of cancer and appears to be an important
component of the transforming growth factor-beta (TGF-ß)-induced tumor suppression pathway. Surprisingly, we found
that RUNX3 expression level in head and neck squamous cell carcinoma (HNSCC) tissues, which is one of the most common
types of human cancer, was higher than that in normal tissues by a previously published microarray dataset in our
preliminary study. Therefore, here we examined the oncogenic role of RUNX3 in HNSCC.
Principal Findings: Frequent RUNX3 expression and its correlation with malignant behavior were observed in HNSCC.
Ectopic RUNX3 overexpression promoted cell growth and inhibited serum starvation-induced apoptosis and
chemotherapeutic drug induced apoptosis in HNSCC cells. These findings were confirmed
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