原创力文档s100b protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milks100b蛋白、脑源性神经营养因子和神经胶质细胞在母乳line-derived神经营养因子.pdfVIP
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s100b protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milks100b蛋白、脑源性神经营养因子和神经胶质细胞在母乳line-derived神经营养因子
S100B Protein, Brain-Derived Neurotrophic Factor, and
Glial Cell Line-Derived Neurotrophic Factor in Human
Milk
1 2 1 1
Ruisong Li , Wei Xia , Zhihong Zhang , Kun Wu *
1 Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China, 2 Department of Children Health and Hygiene, School of
Public Health, Harbin Medical University, Harbin, China
Abstract
Background: Human milk contains a wide variety of nutrients that contribute to the fulfillment of its functions, which
include the regulation of newborn development. However, few studies have investigated the concentrations of S100B
protein, brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) in human milk. The
associations of the concentrations of S100B protein, BDNF, and GDNF with maternal factors are not well explored.
Methodology/Principal Findings: To investigate the concentrations of S100B protein, BDNF, and GDNF in human milk and
characterize the maternal factors associated with their levels in human milk, human milk samples were collected at days 3,
10, 30, and 90 after parturition. Levels of S100B protein, BDNF, and GDNF, and their mRNAs in the samples were detected.
Then, these concentrations were compared with lactation and other maternal factors. S100B protein levels in human milk
samples collected at 3, 10, 30, and 90 d after parturition were 1249.79 6398.10, 1345.056539.16, 1481.83 6573.30, and
1414.396621.31 ng/L, respectively. On the other hand, the BDNF concentrations in human milk samples were 10.99 64.55,
13.0165.88, 13.3566.43, and 2.83 65.47 mg/L, while those of GDNF were 10.90 61.65, 11.3861., 11.2963.10, and
11.4062.21 g/L for the same time periods. Maternal post-pregnanc
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