原创力文档s100a6 protein negatively regulates cacybpsip-mediated inhibition of gastric cancer cell proliferation and tumorigenesiss100a6蛋白负调节cacybpsip-mediated抑制胃癌细胞增殖和肿瘤发生.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
s100a6 protein negatively regulates cacybpsip-mediated inhibition of gastric cancer cell proliferation and tumorigenesiss100a6蛋白负调节cacybpsip-mediated抑制胃癌细胞增殖和肿瘤发生
S100A6 Protein Negatively Regulates CacyBP/SIP-
Mediated Inhibition of Gastric Cancer Cell Proliferation
and Tumorigenesis
1 . 2. 4 3 1 1 1
Xiaoxuan Ning * , Shiren Sun , Kun Zhang , Jie Liang , Yucai Chuai , Yuan Li *, Xiaoming Wang *
1 Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China, 2 Department of Nephrology, Xijing Hospital, Fourth Military Medical
University, Xi’an, Shaanxi, China, 3 State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an,
Shaanxi, China, 4 College of Life Science, Shaanxi Normal University, Xi’an, Shaanxi, China
Abstract
Calcyclin-binding protein (CacyBP/SIP), identified on the basis of its ability to interact with S100 proteins in a calcium-
dependent manner, was previously found to inhibit the proliferation and tumorigenesis of gastric cancer cells in our
laboratory. Importantly, the effects of S100 proteins on the biological behavior of CacyBP/SIP in gastric cancer remain
unclear. Herein, we report the construction of eukaryotic expression vectors for wild-type CacyBP/SIP and a truncated
mutant lacking the S100 protein binding domain (CacyBP/SIPDS100). The expressions of the wild-type and truncated
recombinant proteins were demonstrated by transfection of MKN45 gastric cancer cells. Co-immunoprecipitation assays
demonstrated interaction between S100A6 and wild-type CacyBP/SIP in MKN45 cells. Removal of the S100 protein binding
domain dramatically reduced the affinity of CacyBP/SIP for S100 proteins as indicated by reduced co-immunoprecipitation
of S100A6 by CacyBP/SIPDS100. The MTT a
您可能关注的文档
- rna-seq analysis reveals different dynamics of differentiation of human dermis- and adipose-derived stromal stem cellsrna-seq分析揭示了不同动力学的人类皮肤和脂肪基质干细胞的分化.pdf
- rna-seq analysis of the sclerotinia homoeocarpa – creeping bentgrass pathosystemrna-seq菌核病的分析homoeocarpau2014u2014爬bentgrass pathosystem.pdf
- rna-seq mapping and detection of gene fusions with a suffix array algorithmrna-seq映射和检测的基因融合后缀数组的算法.pdf
- rnaseq analysis of the parasitic nematode strongyloides stercoralis reveals divergent regulation of canonical dauer pathwaysrnaseq分析寄生线虫类圆线虫属stercoralis显示不同的监管规范多尔通路.pdf
- rna-seq analyses generate comprehensive transcriptomic landscape and reveal complex transcript patterns in hepatocellular carcinomarna-seq生成全面的转录组分析景观在肝细胞癌和揭示复杂的转录模式.pdf
- rna-seq reveals an integrated immune response in nucleated erythrocytesrna-seq揭示了一个集成的有核红细胞的免疫反应.pdf
- road traffic injury is an escalating burden in africa and deserves proportionate research efforts道路交通伤害是一个不断升级的负担在非洲和值得比例的研究工作.pdf
- road trauma in teenage male youth with childhood disruptive behavior disorders a population based analysis路创伤与儿童破坏性行为障碍十几岁的男青年人口为基础的分析.pdf
- robust and fast whole brain mapping of the rf transmit field b1 at 7t射频传输的健壮和快速全脑映射字段b1在7 t.pdf
- robust and task-independent spatial profile of the visual word form activation in fusiform cortex健壮和task-independent空间的视觉词形式在梭状回的激活皮层.pdf
- rush to judgment急于判断.pdf
- s phase progression in human cells is dictated by the genetic continuity of dna foci在人类细胞s期进展是由基因的dna疫源地的连续性.pdf
- runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligamentrunx2 haploinsufficiency改善发展的后纵韧带骨化.pdf
- s100b protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milks100b蛋白、脑源性神经营养因子和神经胶质细胞在母乳line-derived神经营养因子.pdf
- rust secreted protein ps87 is conserved in diverse fungal pathogens and contains a rxlr-like motif sufficient for translocation into plant cells锈分泌蛋白质ps87守恒在不同真菌病原体和包含一个rxlr-like主题足以易位到植物细胞.pdf
- sa-4-1bbl costimulation inhibits conversion of conventional cd4+ t cells into cd4+foxp3+ t regulatory cells by production of ifn-γsa-4-1bbl聚集有关抑制转换传统的cd4 + t细胞cd4 + foxp3 + t调节细胞ifn-γ的生产.pdf
- s100a9 knockdown decreases the memory impairment and the neuropathology in tg2576 mice, ad animal models100a9击倒减少tg2576小鼠记忆障碍和神经病理学,ad动物模型.pdf
- rspo1β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovaryrspo1β-catenin信号通路调节oogonia分化和进入减数分裂胎儿卵巢的老鼠.pdf
- saccadic adaptation to moving targets眼跳适应移动目标.pdf
- sabretoothed carnivores and the killing of large prey剑齿食肉动物和杀害大型猎物.pdf
文档评论（0）