原创力文档rspo1β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovaryrspo1β-catenin信号通路调节oogonia分化和进入减数分裂胎儿卵巢的老鼠.pdfVIP
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rspo1β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovaryrspo1β-catenin信号通路调节oogonia分化和进入减数分裂胎儿卵巢的老鼠
RSPO1/b-Catenin Signaling Pathway Regulates Oogonia
Differentiation and Entry into Meiosis in the Mouse Fetal
Ovary
1,2 1,2 1,2 3
Anne-Amandine Chassot , Elodie P. Gregoire , Rowena Lavery , Makoto M. Taketo , Dirk G. de
4,5 6 1,2
Rooij , Ian R. Adams , Marie-Christine Chaboissier *
´ ´ ´ ´
1 INSERM, U636, Nice, France, 2 Universite de Nice-Sophia Antipolis, Laboratoire de Genetique du Developpement Normal et Pathologique, Nice, France, 3 Department of
´
Pharmacology, Graduate School of Medicine, Kyoto University Yoshida-Konoe-cho, Sakyo, Kyoto, Japan, 4 Center for Reproductive Medicine, Academic Medical Center,
Amsterdam, The Netherlands, 5 Department of Endocrinology and Metabolism, Faculty of Science, Utrecht University, Utrecht, The Netherlands, 6 MRC Human Genetics
Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland
Abstract
Differentiation of germ cells into male gonocytes or female oocytes is a central event in sexual reproduction. Proliferation
and differentiation of fetal germ cells depend on the sex of the embryo. In male mouse embryos, germ cell proliferation is
regulated by the RNA helicase Mouse Vasa homolog gene and factors synthesized by the somatic Sertoli cells promote
gonocyte differentiation. In the female, ovarian differentiation requires activation of the WNT/b-catenin signaling pathway
in the somatic cells by the secreted protein RSPO1. Using mouse models, we now show th
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